Treated with saline, AII, BDZ, or AII + BDZ. (B) Myometrial spiral

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Treated with saline, AII, BDZ, or AII + BDZ. (B) Myometrial spiral artery endothelium replaced by EVT ( perimeter) in dams treated with saline, AII, BDZ, or AII + BDZ. Continuous line represents mean values. **P < 0.005; ***P < 0.0005.Discussion The results of the present study indicate that a transient disruption of the balance between the RAS and the KKS in favor of the RAS in midpregnancy alters the maternal adaptation to pregnancy. At the level of the utero-placental unit, tilting the RAS/ KKS balance towards vasoconstriction caused fetal losses and placental insufficiency, and reduced the replacement of endothelium by endovascular trophoblasts in the spiral arteries. Infusions were del.Treated with saline, AII, BDZ, or AII + BDZ. (B) Myometrial spiral artery endothelium replaced by EVT ( perimeter) in dams treated with saline, AII, BDZ, or AII + BDZ. Continuous line represents mean values. **P < 0.005; ***P < 0.0005.Discussion The results of the present study indicate that a transient disruption of the balance between the RAS and the KKS in favor of the RAS in midpregnancy alters the maternal adaptation to pregnancy. At the level of the utero-placental unit, tilting the RAS/ KKS balance towards vasoconstriction caused fetal losses and placental insufficiency, and reduced the replacement of endothelium by endovascular trophoblasts in the spiral arteries. Infusions were del.